Platelet-rich fibrin (PRF) to treat periodontal intrabony defects?


36 intrabony defects in 36 individual patients were treated with either demineralized freeze-dried bone allograft (DFDBA) or platelet-rich fibrin (PRF).  Data was collected at baseline and at 6 month follow up and included radiographic bone fill and changes in clinical attachment levels (CAL).


Both treatment groups had significant gain in clinical attachment levels and bone fill, with no significant difference between groups.  Mean CAL gain for DFDBA was 1.16 ± 1.33 mm and mean radiographic bone fill was 1.14 ± 0.88 mm.  PRF had a mean CAL gain of 1.03 ± 0.86 and mean radiographic bone fill of 1.10 ± 1.01 mm.


Intrabony defects treated with either DFDBA or PRF had a significant gain in CAL as well as bone fill after 6 months of healing and there was no significant difference between the two materials.

For more information please refer to:

Journal of Periodontology, November 2016, Vol. 87, No. 11

Clinical and Radiographic Evaluation of Demineralized Freeze-Dried Bone Allograft Versus Platelet-Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans

Jane K. Chadwick, Michael P. Mills,  and Brian L. Mealey

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