52 patients with at least one non-contained infrabony defect ≥ 3 mm and probing ≥ 3 mm were randomly treated with either Emdogain plus biphasic calcium phosphate or Emdogain alone. The primary outcome was a change in clinical attachment up to 12 months.
Mean clinical attachment gain of 2.38 mm ± 2.17 mm was achieved in the Emdogain plus calcium phosphate group compared to 2.65 ± 2.18 mm when Emdogain was used alone. There was no statistically significant difference between the two treatment groups.
The treatment of non-contained infrabony defects with Emdogain combined with calcium phosphate did not yield statistically significant improvement compared to Emdogain used by itself. Both treatment resulted in significantly better clinical attachment levels at 12 months.
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J Periodontol. 2017 May;88(5)
Treatment of Non-Contained Infrabony Defects With Enamel Matrix Derivative Alone or in Combination With Biphasic Calcium Phosphate Bone Graft: A 12-Month Randomized Controlled Clinical Trial
Losada M, González R, Garcia AP, Santos A, Nart J